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September 1, 1990Journal of Medicinal Chemistry

Heterosubstituted anthracene-9,10-dione analogs. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4,9-diones

A. Paul Krapcho M. E. PETRY Miles P. Hacker

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Abstract

A number of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4, 9-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Two of the congeners exhibited in vivo activities quite comparable to that of mitoxantrone.

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Krapcho et al. (1990) studied this question.

synapsesocial.com/papers/6a96cdec0e1155e7755797ac https://doi.org/10.1021/jm00171a048

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