Although allergic reactions to copper are rare, skin disorders may appear or worsen during the perimenstrual period. This paper presents the case of a 41-year-old user of a copper-containing IUD who presented with a history of recurrent, self-healing skin eruption associated with abdominal pain. The eruption followed a cyclical pattern, appearing 3-7 days before menses and improving spontaneously with the onset of bleeding. Patch testing revealed a positive reaction to copper sulfate and nickel sulfate. After the IUD was removed, abdominal symptoms subsided at the next cycle and progressive resolution of the dermatitis was observed.
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Pujol et al. (1998) studied this question.
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