⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

July 3, 2019Science Translational Medicine

CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection

Sebastián A. Riquelme Carmen Lozano Ahmed M. Moustafa Kalle Liimatta Kira L. Tomlinson Clemente J. Britto Sara Khanal Simren K. Gill Apurva Narechania José Manuel Azcona Emily DiMango Yolanda Sáenz Paul J. Planet

View at Publisher

Ask AI

Bookmark

Share

Abstract

Excess succinate due to CFTR-PTEN dysfunction selects for Pseudomonas aeruginosa mutants adapted to the airway.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Riquelme et al. (2019) studied this question.

synapsesocial.com/papers/6a96ce9750562539420e1d29 https://doi.org/10.1126/scitranslmed.aav4634

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient MiceOriginal Research · 2016 · 44 citations
2HIF1α and metabolic reprogramming in inflammationOriginal Research · 2016 · 784 citations
3Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate LevelsOriginal Research · 2016 · 520 citations
4GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritisOriginal Research · 2016 · 514 citations
5Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Signaling Regulates Mitochondrial Biogenesis and Respiration via Estrogen-related Receptor α (ERRα)Original Research · 2013 · 58 citations

Carbon catabolite repression in<i>Pseudomonas</i>: optimizing metabolic versatility and interactions with the environment2010
Isolation and characterization of catabolite repression control mutants of Pseudomonas aeruginosa PAO1991
The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by <i>Pseudomonas aeruginosa</i>2000
Dengue virus controlled human challenge reveals that preexisting immunity shapes viral replication and broadly protective responsesScience Translational Medicine · 2026
Brain-sensing synNotch–CAR T cells enable precise targeting and clearance of diffuse midline glioma in multiple preclinical modelsScience Translational Medicine · 2026

More from Science Translational Medicine

More from University of Pennsylvania

More from Columbia University

More from Yale University

More from Children's Hospital of Philadelphia

More from American Museum of Natural History

More from Hospital San Pedro

More from Center for Biomedical Research of La Rioja