Aging is the result of combined changes in many biological processes that are associated with impaired functional status in humans and increase the risk of chronic pathologies. Since there are a number of insurmountable difficulties in conducting clinical studies on humans, it is necessary to resort to experimental modeling of key signs of aging and associated pathologies. However, all the used models of aging are far from perfect, since there are a number of factors that do not allow a full comparison of the mechanisms of the aging process in humans and animals. This article presents the main experimental models of aging and determines their advantages and disadvantages in the context of potential studies.
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Garanin et al. (2025) studied this question.
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