What question did this study set out to answer?

To evaluate the efficacy and stability of oral khellin photochemotherapy paired with natural sunlight exposure for inducing repigmentation in patients with vitiligo.

October 14, 2009Dermatologica

An Approach to the Treatment of Vitiligo by Khellin

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To evaluate the efficacy and stability of oral khellin photochemotherapy paired with natural sunlight exposure for inducing repigmentation in patients with vitiligo.
Conducted a double-blind clinical study administering oral khellin daily for 4 months to vitiligo patients (N=30) followed by natural sunlight exposure.
Compared outcomes against control subjects (N=30) and monitored responders for 1 year after drug cessation to evaluate repigmentation stability.
In the khellin group (N=30), 16.6% (5/30) achieved 90–100% repigmentation, 23.3% (7/30) repigmented 50–60%, 36.6% (11/30) repigmented ≤25%, and 23.3% (7/30) showed no response.
In the control group (N=30), 0% (0/30) exhibited repigmentation.
Skin repigmentation achieved during the 4-month treatment window remained stable for 1 year following khellin cessation.

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Implication

Double-blind trial demonstrates sustained skin repigmentation following oral khellin and sunlight exposure in vitiligo patients, suggesting a non-psoralen therapeutic alternative.

Cite This Study

Abdelfattah et al. (2009) studied this question.

synapsesocial.com/papers/6a96d501ec20a28d6d822f68 https://doi.org/10.1159/000249932

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Implication

Double-blind trial demonstrates sustained skin repigmentation following oral khellin and sunlight exposure in vitiligo patients, suggesting a non-psoralen therapeutic alternative.

An Approach to the Treatment of Vitiligo by Khellin

Key Points

Discussion

Implication

Cite This Study

An Approach to the Treatment of Vitiligo by Khellin

Key Points

Discussion

Implication

Cite This Study

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