Key result
Selective initiation of phasic contractions by U46619 depends on intracellular Ca2+ from a ryanodine-sensitive store, whereas tonic contractions are mediated by IP3-mobilized intracellular Ca2+.
The study identifies distinct intracellular calcium pools regulating tonic versus phasic contractions in the porcine thoracic duct.
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Distinguishes Ca2+ stores for phasic versus tonic lymphatic contractions in pigs; hypothesis-generating for vessel motility mechanisms pending human validation.
Moffatt et al. (2003) studied Pig thoracic duct physiology. U46619 and 5-hydroxytryptamine (5-HT) was evaluated on Phasic and tonic contractions. Selective initiation of phasic contractions by U46619 depends on intracellular Ca2+ from a ryanodine-sensitive store, whereas tonic contractions are mediated by IP3-mobilized intracellular Ca2+.
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