Pancreatitis Associated with Isotretinoin-lnduced Hypertriglyceridemia

Brief Reports1 July 1987Pancreatitis Associated with Isotretinoin-lnduced HypertriglyceridemiaWILLIAM J. FLYNN, M.D., PAMELA G. FREEMAN, M.D., LLOYD G. WICKBOLDT, M.D.WILLIAM J. FLYNN, M.D., PAMELA G. FREEMAN, M.D., LLOYD G. WICKBOLDT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-1-63 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIsotretinoin (Accutane; Roche Laboratories, Nutley New Jersey) is a vitamin A derivative useful in the treatment of skin disorders caused by follicular occlusion. Isotretinoin is most frequently prescribed for recalcitrant nodulocystic acne ( 1 ). Elevation of the serum triglyceride level has been previously reported (2). We report a case of pancreatitis precipitated by hypertriglyceridemia associated with isotretinoin therapy.A 43-year-old white woman had a 10-year history of nodulocystic acne and hidradenitis suppurativa refractory to oral tetracyclines and topical therapy. Isotretinoin had been instituted at 40 mg orally twice daily (1.0 mg/kg bodyweight · d) after baseline fasting laboratory studies...References1. SPEARMULLER LS. Treatment of cystic acne with 13-cis-retinoic acid. Mayo Clin Proc. 1983;58:509-14. MedlineGoogle Scholar2. ZECHGROSSPECKBREWER LEGH. Changes in plasma cholesterol and triglyceride levels after treatment with oral isotretinoin: a prospective study. Arch Dermatol. 1983;119:987-93. CrossrefMedlineGoogle Scholar3. Physicians Desk Reference. 41st ed. Oradell, New Jersey: Medical Economics; 1987. Google Scholar4. LAMMERCHENHOAR EDR. Retinoic acid embryopathy. N Engl J Med. 1985;313:837-41. CrossrefMedlineGoogle Scholar5. KATZJORGENSENNIGRA RHT. Elevation of serum triglyceride levels from oral isotretinoin in disorders of keratinization. Arch Dermatol. 1980;116:1369-72. CrossrefMedlineGoogle Scholar6. DICKENCONNOLLY HS. Eruptive xanthomas associated with isotretinoin (13 cis-retinoic acid). Arch Dermatol. 1980;116:951-2. CrossrefMedlineGoogle Scholar7. BESHADRUBINSTEINPATERNITI SAJ. Changes in plasma lipid and lipoproteins during isotretinoin therapy for acne. N Engl J Med. 1985;313:981-5. CrossrefMedlineGoogle Scholar8. DICKEN C. Elevation of blood triglyceride levels secondary to administration of vitamin A [Letter]. Arch Dermatol. 1981;117:189-90. CrossrefMedlineGoogle Scholar9. MALLORYKERN AF. Drug-induced pancreatitis: a critical review. Gastroenterology. 1980;78:813-21. CrossrefMedlineGoogle Scholar10. URBANIAK S. Therapeutic plasma and cellular apheresis. Clin Haematol. 1984;13:217-51. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Orlando Regional Medical Center Orlando, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPancréatite aiguë sous acitrétineDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsPropofol Infusion and Acute Pancreatitis: A ReviewHypertriglyceridemia-Associated Drug-Induced Acute PancreatitisHypertriglyceridemic pancreatitis: Epidemiology, pathophysiology and clinical managementNot every patient needs a triglyceride check, but all can get pancreatitis: a systematic review and clinical characterization of isotretinoin-associated pancreatitisIsotretinoin: controversies, facts, and recommendationsStandardized laboratory monitoring with use of isotretinoin in acneSafety Considerations and Monitoring in Patients Treated with Systemic Medications for AcneVitamin A: RetinoidsSevere/Extreme Hypertriglyceridemia and LDL Apheretic Treatment: Review of the Literature, Original FindingsAcute PancreatitisTriglycerides and Cardiovascular DiseaseHypertriglyceridemic Pancreatitis: Presentation and ManagementPreventing and Managing the Side Effects of IsotretinoinDrug-Induced PancreatitisDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewAn Adolescent with Abdominal Pain Taking Isotretinoin for Severe AcneDevelopmental and Metabolic Disorders of the PancreasHypertriglyceridemia-induced pancreatitis: A case-based reviewPlasmapheresis as an Adjuvant Therapy for Hypertriglyceridemia-Induced PancreatitisClinical practice guidelines for managing dyslipidemias in kidney transplant patients: a report from the Managing Dyslipidemias in Chronic Kidney Disease Work Group of the National Kidney Foundation Kidney Disease Outcomes Quality InitiativeTreatment of acne with isotretinoin: Recommendations based on Australian experienceREFERENCESPlasmapheresis for the treatment of acute pancreatitis induced by hemophagocytic syndrome related to hypertriglyceridemiaIssues in Hyperlipidemic PancreatitisSafety issues in isotretinoin therapyAcute and Chronic Pancreatitis in Patients with Inborn Errors of MetabolismManagement of PancreatitisThe Endocrine Effects of Nonhormonal Antineoplastic TherapyActivity of serum lipase EC 3.1.1.3 in psoriatic malesPlasma Exchange for Dramatic Gestational Hyperlipidemic PancreatitisTreatment of severe familial hypertriglyceridemia during pregnancy with very-low-fat diet and n-3 fatty acidsReview article: Drug-induced pancreatitisMolecular pathobiology of the human lipoprotein lipase geneComa acidocétosique, mode de découverte d'une pancréatite aiguë sévère chez un patient non diabétique prenant de l'acitrétineDysfibrinogénémie et thrombocytopénie transitoires associées à une pancréatite aiguë récidivante lors d'un traitement par l'isotrétinoïneIsotretinoin therapy for acne vulgaris: a re-evaluation of the need for measurements of plasma lipids and liver function testsMonitoring for adverse effects from systemic drugs used in dermatologyAcne Vulgaris: Pathogenesis and TreatmentPancreatitis related to severe acute hypertriglyceridemia during pregnancy: Treatment with lipoprotein apheresisHyperlipidemic PancreatitisSerum lipid elevation during isotretinoin therapy for acne in the West of ScotlandDrug-Induced Acute PancreatitisDermatological drugs and cosmetics 1 July 1987Volume 107, Issue 1Page: 63-63KeywordsAcnePancreatitisSerum triglyceridesTetracyclinesVitamin A Issue Published: 1 July 1987 PDF downloadLoading ...