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November 1, 2000Journal of Biological ChemistryOpen Access

Glucosylceramide Synthase Does Not Attenuate the Ceramide Pool Accumulating during Apoptosis Induced by CD95 or Anti-cancer Regimens

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Authors

ATAnnemiek D. TepperThe Netherlands Cancer InstituteSDSander H. DiksUniversity Medical Center GroningenWBWim J. van BlitterswijkThe Netherlands Cancer Institute

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Tepper et al. (2000) studied this question.

synapsesocial.com/papers/6a96dfb531394ac286fbdb1bhttps://doi.org/10.1074/jbc.m005142200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver1991 · 278 citations
  2. 2Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.1992 · 344 citations
  3. 3Tumor Necrosis Factor Induces Ceramide Oscillations and Negatively Controls Sphingolipid Synthases by Caspases in Apoptotic Kym-1 Cells1998 · 98 citations
  4. 4Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells1999 · 270 citations
  5. 5Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis2000 · 282 citations