methodologies, such as docking, molecular dynamics simulations, and MM-GBSA rescoring, were implemented to evaluate the interaction profiles of these compounds with key skin disorder-related enzymes, including elastase, tyrosinase, hyaluronidase, and xanthine oxidase. Complementary in vitro and in vivo assays confirmed the potent antioxidant, anti-inflammatory, and wound-healing properties of the selected extracts. Furthermore, the project underscores sustainable practices by establishing organic cultivation protocols and pilot-scale production processes, ensuring the eco-friendly exploitation of natural resources. By fostering extensive collaboration between academic institutions and industry partners under the Horizon 2020 framework, EthnoHERBS not only advances scientific research and innovative product development but also serves as a model for preserving traditional knowledge and biodiversity.
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Zouraris et al. (2025) studied this question.
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