What question did this study set out to answer?

To determine whether array-based epigenetic aging indices, specifically the Levine PhenoAge clock, are influenced by heritable genetic ancestry and introduce bias into cross-race health evaluations.

June 22, 2020GenesOpen Access

Array-Based Epigenetic Aging Indices May Be Racially Biased

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Authors

RPRobert A. PhilibertUniversity of Iowa SBSteven R. H. BeachUniversity of Georgia MLMan‐Kit LeiUniversity of Georgia

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Implication

Cohort analysis reveals ancestry-linked DNA methylation within the PhenoAge index across newborns and adults, suggesting epigenetic aging clocks may bias cross-race comparisons.

Key Points

To determine whether array-based epigenetic aging indices, specifically the Levine PhenoAge clock, are influenced by heritable genetic ancestry and introduce bias into cross-race health evaluations.
Measured DNA methylation across 513 Levine PhenoAge probes in cord blood collected from 203 newborns (112 African American and 91 White).
Evaluated race-associated CpG sites for correlation with percentage European genetic ancestry in a separate cohort of 505 African American adults.
After Bonferroni correction, 50 CpG sites were significantly associated with ethnicity in newborns, with the top 5 sites predicting ancestry with a receiver operator characteristic area under the curve of 0.97.
Analysis of the 50 identified sites in the adult African American cohort demonstrated that methylation levels at 11 sites were significantly associated with percentage European ancestry.

Cite This Study

Philibert et al. (2020) studied this question.

synapsesocial.com/papers/6a96e09996bab72bf50e4741 https://doi.org/10.3390/genes11060685

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Implication

Cohort analysis reveals ancestry-linked DNA methylation within the PhenoAge index across newborns and adults, suggesting epigenetic aging clocks may bias cross-race comparisons.

Array-Based Epigenetic Aging Indices May Be Racially Biased

Discussion

Member takes

Implication

Key Points

Cite This Study

Array-Based Epigenetic Aging Indices May Be Racially Biased

Discussion

Member takes

Implication

Key Points

Cite This Study

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