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Administration of concen-trated NaCl solutions causes generalized tissue edema and nephrosclerosis in young chicks. Desoxycorticosterone acetate (D.C.A.) exerts a similar effect even on a normal salt intake and sensitizes chicks to the action of sub-threshold concentrations of NaCl. Among a number of steroid preparations tested for this effect only progesterone was found to possess this activity and even this compound was not quite as active as D.C.A.
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Selye et al. (1943) studied this question.
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