Site-specific cleavage of the circular DNA genome of papova viruses has been postulated to occur in a variety of processes, including both initiation and termination of replication, integration into host cell DNA, and excision, when autonomous replication can be induced from the integrated state. From studies on the early thermosensitive mutant ts A of polyoma (Cuzin et al. 1970; Stoker and Dulbecco 1969), it was suggested that the viral genome could code for a site-specific endonuclease involved in the control of DNA replication as well as in the integration/excision process.
No takes yet. Share an insight, caveat, or question.
Parodi et al. (1974) studied this question.