The axoplasmic transport of aromatic l‐amino acid decarboxylase and dopamine β‐hydroxylase, two enzymes involved in the biosynthesis of catecholamines, was studied in rat sciatic nerve. The two enzymes exhibited markedly different axoplasmic flow characteristics, since dopamine β‐hydroxylase activity accumulated on the proximal side of a ligation nearly three times as fast as aromatic l‐amino acid decarboxylase activity. Distally dopamine β‐hydroxylase activity remained essentially constant for 24 h, whereas aromatic l‐amino acid decarboxylase activity fell precipitously. Evidence was obtained to rule out the possibility that differences in the rate of inactivation of the two enzymes could account for the different rates of accumulations observed. The conclusion, that aromatic L‐amino acid decarboxylase and dopamine β‐hydroxylase are transported in sympathetic nerve at different rates is discussed in relation to the biosynthesis of norepinephrine.
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Dairman et al. (1973) studied this question.
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