// Yingying Lu 1,* , Bingjue Li 1,* , Qixia Shen 1 , Rending Wang 1 , Zhimin Chen 1 , Hong Jiang 1 and Jianghua Chen 1 1 Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, P.R. China * These authors have contributed equally to this work Correspondence to: Jianghua Chen, email: // Hong Jiang, email: // Keywords : CD20+ B cell, kidney transplantation, acute rejection, graft loss, steroid resistance Received : September 23, 2016 Accepted : March 04, 2017 Published : March 15, 2017 Abstract The effects of CD20+ B-cell infiltration during acute rejection on graft outcomes are controversial. The objective of this systematic review and meta-analysis was to clarify this issue. We performed a systematic literature search for studies published up to January 14, 2016. A total of 5 studies, with 200 patients, were included. The presence of CD20+ B cells in renal biopsies during allograft rejection was associated with graft loss and steroid resistance. No association of CD20+ B-cell infiltration with C4d-positive staining of the peritubular capillaries in renal biopsies was found in the analysis of patients who experienced kidney graft rejection. In conclusion, CD 20+ B cell infiltration during allograft rejection was associated with an increased risk of graft loss and steroid resistance.
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