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August 1, 2007HaematologicaOpen Access

Demonstration of changes in plasma cell subsets in multiple myeloma

M J Ayliffe Faith E. Davies Denis de Castro Gareth J. Morgan

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Abstract

Increases in free light chain (FLC) production are associated with disease progression in multiple myeloma (MM). Using a double immunofluorescence staining method to produce a differential count of plasma cells in bone marrow, single populations were demonstrated, containing intact monoclonal immunoglobulins (M-Igs) in 74% and FLCs only in 8% of cases. However, 18% contained a mixture of both cell populations. Progression from cells making intact M-Ig to cells restricted to FLC only production occurred in individual cases during the course of their disease. The presence of FLC only cells was associated with shortened survival.

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Ayliffe et al. (2007) studied this question.

synapsesocial.com/papers/6a96e60418d06551b502285b https://doi.org/10.3324/haematol.11133

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