All articles of this category A three-step procedure for the synthesis of enantiomerically pure 2-substituted N -tosylaziridines 4 is described. The method involves N -tosylation of (S)-2-amino acids 1 , followed by reduction to give N -tosyl-2-amino alcohols 3 and O -tosylation with in situ aziridine ring closure.
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Berry et al. (1992) studied this question.