Development of a BALB/c mouse model for food allergy: comparison of allergy-related responses to peanut agglutinin, β-lactoglobulin and potato acid phosphatase

< 0.001 for specific IgG1), whereas parameters in those treated with β-LG were between the other two. Statistically higher histamine release was observed in PNA and β-LG-sensitized mice than in control mice challenged with the same protein by i.p. injection. Intraperitoneal challenge with PNA and β-LG in sensitized mice induced edema in the ear and inflammatory cell infiltration in the lung, which were not observed with the control mice. The results show a new model that covers many features of clinical food allergies that are not seen in other models. The order of potential allergenicity might be PNA > β-LG > PAP, and the intraperitoneal challenge could be more sensitive to induced systemic food allergy.