Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

We report an original strategy to transcribe and to fix the self-assembly of G-quadruplex architectures in self-organized nanohybrids. In the first resolution step the G-quartet is pre-amplified in solution in the presence of metal cations from a dynamic pool of ribbon-type or cyclic supramolecular architectures. Then in a second selection sol–gel step the G-quadruplex is irreversibly fixed in a siloxane inorganic network. The interface between the guanosine moiety and the heterosiloxane 3 is based on a double reversible covalent iminoboronate connection. This contributes to the high levels of adaptability and correlation in the self-organization of the supramolecular G-quadruplex and the inorganic siloxane systems. Biomimetic-type hybrids can be generated by using this strategy.