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August 31, 2026Journal of Cardiovascular ImagingOpen Access

Echocardiography requires sex-specific reference values to accurately diagnose cardiovascular disease in women.

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Why the study?

In women, smaller cardiac size, higher baseline ejection fraction, and technical limitations may affect echocardiographic interpretation across relevant cardiovascular conditions.

Design

Review

Key result

Echocardiography is the primary imaging modality for evaluating cardiovascular disease in women, requiring consideration of sex-specific physiological differences and reference values for accurate diagnosis.

Authors

SKSo Ree KimSPSeong-Mi Park

Discussion

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Overview

Echocardiography aids evaluation of female-specific CVD; leaves open prospective validation of sex-specific norms before broader guideline adoption.

Structured PICO

P
Population
Women with or at risk for cardiovascular conditions, including heart failure with preserved ejection fraction, coronary microvascular dysfunction, pulmonary hypertension, valvular heart disease, stress-induced cardiomyopathy, and pregnancy-related changes
I
Intervention
Echocardiography

Echocardiography is a crucial, safe imaging modality for evaluating cardiovascular diseases in women, though specific physiological differences like smaller cardiac size and higher baseline ejection fraction must be considered during interpretation.

Limitations

  • Image quality may be compromised by poor acoustic windows or attenuation from breast tissue or breast implants.
  • The technique remains operator-dependent, introducing potential variability in measurements.
  • Women have higher false-positive rates during stress echocardiography.

Cite This Study

Kim et al. (2026) conducted a review in Cardiovascular disease in women. Echocardiography was evaluated. Echocardiography is the primary imaging modality for evaluating cardiovascular disease in women, requiring consideration of sex-specific physiological differences and reference values for accurate diagnosis.

synapsesocial.com/papers/6a96f058c00de92d9bfbd852https://doi.org/10.1186/s44348-026-00091-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex-specific echocardiographic reference values: the women's point of view2018 · 25 citations
  2. 2Role of Echocardiography in the Management of Cardiac Disease in Women2014 · 7 citations
  3. 3Role of Echocardiography in Assessing Pregnant Women With and Without Heart Disease2008 · 7 citations
  4. 4Echocardiography in Pregnancy: Part 22016 · 19 citations
  5. 5Clinical Applications of Echocardiography1977 · 3 citations