Key result
Nitric oxide potently and reversibly inhibited thrombin-induced platelet shape change through the activation of protein kinase A and subsequent VASP Ser157 phosphorylation.
This study demonstrates that nitric oxide inhibits thrombin-induced platelet shape change via a PKA-dependent pathway, providing mechanistic insights into platelet regulation.
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Offers no clinical guidance; leaves open translation of nitric oxide effects on platelets to human thrombosis.
Jensen et al. (2004) studied this question. Nitric oxide was evaluated on Thrombin-induced platelet shape change. Nitric oxide potently and reversibly inhibited thrombin-induced platelet shape change through the activation of protein kinase A and subsequent VASP Ser157 phosphorylation.
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