Guillain-Barre Syndrome Following Smallpox Vaccination

JENNERIAN vaccination has for many years been a widely practiced procedure, with few complicating sequelae. The usual complication consists of painful local inflammation with regional lymphadenopathy and fever, but occasionally Kaposi's varicelliform eruption and acute disseminated encephalomyelitis occur.1 It is the purpose of this paper to report a case in which smallpox prophylaxis was followed by the development of the Guillain-Barré syndrome. A review of the literature reveals that this complication has been described only twice previously.2 , 3 Recent experimental work suggests that the occurrence of this type of polyradiculoneuropathy may have an immunologic basis.4 This case appears to lend clinical . . .