Synthesis of deuterioporphyrin IX, pemptoporphyrin, and spirographis porphyrin dimethyl esters

Our stepwise porphin synthesis has been used for the preparation of three porphins, including deuterioporphyrin IX dimethyl ester, containing one or two unsubstituted β-positions, and three β-vinylporphins, including pemptoporphyrin dimethyl ester and spirographis porphyrin dimethyl ester. The vinyl substituents have been introduced through β-dimethylaminoethyl groups by Hofmann degradations.