Key result
Electrochemical array-based primer extension using labelled dideoxy nucleotides successfully confirmed immobilised primer extension for all four ddNTPs to detect SNPs in the MYH7 gene.
Demonstrates a potentially cost-effective electrochemical platform for screening disease-specific SNPs in the MYH7 gene.
We report the labelling of dideoxy nucleotides (ddNTPs) for use in electrochemical array based primer extension for the detection of single nucleotide polymorphisms (SNPs). The results confirm the extension of the immobilised primers for each of the four ddNTPs, representing a significant advance in achieving a cost-effective platform for screening of disease-specific SNPs.
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Debela et al. (2015) studied this question. Electrochemical array-based primer extension using labelled dideoxy nucleotides successfully confirmed immobilised primer extension for all four ddNTPs to detect SNPs in the MYH7 gene.
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