Key result
Initiation of medical therapy for hypercalcemia unmasked a prolonged QT interval, allowing for the diagnosis of long-QT syndrome in a patient with Williams Syndrome.
Case Report (n=1)
Hypercalcemia can pseudo-normalize the QTc interval on surface ECG, potentially concealing underlying long-QT syndrome.
Correcting hypercalcemia may unmask concealed long-QT syndrome in Williams syndrome; this case leaves open whether routine QT monitoring is warranted.
We report a case of gene-positive long-QT syndrome (KCNH2) in a patient with concomitant Williams Syndrome. The hypercalcemia that developed in association with Williams Syndrome pseudo-normalized the QTc interval on surface ECG, concealing the clinical and electrocardiographic manifestations of the disease. Initiation of medical therapy for hypercalcemia unmasked the prolonged QT interval, allowing for the diagnosis of long-QT syndrome to be made.
No takes yet. Share an insight, caveat, or question.
Czosek et al. (2008) conducted a case report in Congenital Long-QT Syndrome and Williams Syndrome (n=1). Medical therapy for hypercalcemia was evaluated on QTc interval unmasking. Initiation of medical therapy for hypercalcemia unmasked a prolonged QT interval, allowing for the diagnosis of long-QT syndrome in a patient with Williams Syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: