Registry for the Microangiopathic Hemolytic Syndrome Associated with Cancer Chemotherapy

Letters and Corrections1 November 1984Registry for the Microangiopathic Hemolytic Syndrome Associated with Cancer ChemotherapyJAMES H. KELLER, Pharm. D., IRA WEINSTEIN, M.D.JAMES H. KELLER, Pharm. D.Search for more papers by this author, IRA WEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-716_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Jackson and associates (1) reported five patients who developed a microangiopathic hemolytic anemia with renal insufficiency and thrombocytopenia after treatment with cisplatin, bleomycin, and a vinca alkaloid. Of the five patients, one had thrombotic thrombocytopenia purpura and the other four developed the hemolytic-uremic syndrome. Two patients had an indolent course and three patients died of complications related to the syndrome. All patients had minimal or nondetectable disease at the onset of the thrombotic microangiopathy.A number of investigators (2, 3) have also reported the syndrome in other types of malignant diseases treated with different chemotherapeutic regimens. Microangiopathic...References1. JACKSONROSEGRAFF ABL. Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. Ann Intern Med. 1984;101:41-4. LinkGoogle Scholar2. KRESSELRYANDUONG BKA. Microangiopathic hemolytic anemia, thrombocytopenia, and renal failure in patients treated for adenocarcinoma. Cancer. 1981;48:1738-45. CrossrefMedlineGoogle Scholar3. JOLIVETGIROUXLAURIN JLS. Microangiopathic hemolytic anemia, renal failure, and noncardiogenic pulmonary edema: a chemotherapy-induced syndrome. Cancer Treat Rep. 1983;67:429-34. MedlineGoogle Scholar4. CANTRELSCHEINWINOKARPHILLIPS JPST. Cancer-related thrombotic microangiopathy: natural history and therapy [Abstract]. Proc Am Soc Clin Oncol. 1983;2:12. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES H. KELLER, Pharm. D.; IRA WEINSTEIN, M.D.Affiliations: Medical Department, Bristol Laboratories Syracuse, NY 13221 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThrombotic Microangiopathy Associated with Chemotherapy: Case Report and Review of the Literature 1 November 1984Volume 101, Issue 5Page: 716-716KeywordsAlkaloidsCancer chemotherapyCancer treatmentHemolytic anemiaHemolytic-uremic syndromeRenal cancer ePublished: 1 December 2008 Issue Published: 1 November 1984 PDF downloadLoading ...