Platelet-Aggregating Factor in Thrombotic Thrombocytopenic Purpura

Letters and Corrections1 April 1985Platelet-Aggregating Factor in Thrombotic Thrombocytopenic PurpuraJAMES N. ATKINS, M.D.JAMES N. ATKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: the interesting article by Dr. Kelton and colleagues (1) concerning the detection of platelet-aggregating factor in thrombotic thrombocytopenic purpura raises two questions that I hope they will clarify.First, when they evaluated aggregation, did they control for isoagglutins? Their article indicated that when they pooled platelets they used ABO-compatible donors, but did the aggregation studies use ABO-compatible platelets with ABO-appropriate serum and cryoprecipitate?Second, why did they use an endpoint of visible agglutination rather than using phase microscopy to look for agglutination or using an aggretometer as Dr. Lain and colleagues (2) did in their study? Visible...References1. KELTON J, MORE J, SANTOS A, and SHERIDAN D. Detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. Ann Intern Med. 1984;101:589-93. LinkGoogle Scholar2. LAIN EC, HARKNESS D, BYRNES J, WALLACH H, and NUNEZ R. Presence of a platelet aggregating factor in the plasma of patients with thrombotic thrombocytopenic purpura (TTP) and it's inhibition by normal plasma. Blood. 1979;53:333-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES N. ATKINS, M.D.Affiliations: Goldsboro Medical Specialists Goldsboro, NC 27530 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlood Diseases and Neurologic Symptoms 1 April 1985Volume 102, Issue 4Page: 560-561KeywordsMicroscopyPlateletsThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 April 1985 PDF downloadLoading ...