The cardiovascular effects of PGE1, PGA1, and PGFF2α were studied in anesthetized, open chest dogs. It was found that PGE1, PGA1, and PGFF2α decrease left atrial pressures, and increase heart rate, pulmonary arterial pressure, cardiac output, and myocontractile force. However, both PGE1 and PGA1 are vaso-dilators and decrease systemic arterial pressure. The multiple hemodynamic changes induced by the three prostaglandins are caused, not only by their direct effect on the peripheral vasculatures, but also by their effects on the myocardium.
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Nakano et al. (1968) studied this question.