Key result
Nuclear export of hnRNP A1 requires energy, is independent of Crm1, and is accelerated by the inhibition of splicing or transcription.
Population
In vitro and in vivo models studying the nuclear export of the mRNA-binding protein hnRNP A1
Comparison
snRNA-specific oligonucleotides or inhibition of… vs Unsupplemented incubations / control conditions
Design
Preclinical
Authors
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Animal data extend hnRNP A1 shuttling mechanisms; leaves open relevance to human disease or therapy.
Inhibition of transcription or splicing accelerates the nuclear export of hnRNP A1, providing a mechanistic explanation for the cytoplasmic relocation of RNA-binding proteins upon transcription inhibition.
Lichtenstein et al. (2001) studied this question. Inhibition of splicing or transcription was evaluated on Nuclear export of hnRNP A1. Nuclear export of hnRNP A1 requires energy, is independent of Crm1, and is accelerated by the inhibition of splicing or transcription.
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