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Using a computer‐aided procedure of analyzing labeled mitoses data, a comparison was made between the proliferative characteristics of solid transplanted BICR/MIRK rat tumors grown in immunocompetent or anti‐thymocyte serum treated hosts. The tumors were primary re‐implants of cells from a permanent cell culture line (BICR/MIRK; 70th passage), originating from a transplantable rat mammary tumor (BICR/MIR) which was also included in the study. The results are discussed in relation to the influence of the host immune system on the rates of cell production and cell loss, the cell cycle parameters, and the distributions of cell cycle times, derived for these tumors.
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Rajewsky et al. (1972) studied this question.
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