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Biochemical study reveals how Helicobacter pylori modulates heptose metabolite synthesis during host interaction, highlighting potential therapeutic targets against infection and inflammation.
PAI), contact with human cells, and the carbon starvation regulator A. Reconstitution with purified biosynthesis enzymes and purified bacterial lysates allowed us to biochemically characterize heptose pathway products, identifying a heptose-monophosphate variant as a novel proinflammatory metabolite. These findings emphasize that the bacteria use heptose biosynthesis to fine-tune inflammation and also highlight opportunities to mine the heptose biosynthesis pathway as a potential therapeutic target against infection, inflammation, and cancer.
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Hauke et al. (2023) studied this question.
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