Key result
APOBEC3 selection pressure impacts at least 22% of all currently annotated human viral species, leaving an evolutionary footprint characterized by the depletion of APOBEC3-favored motifs.
Why the study?
The study aimed to identify human viruses whose genomes have been shaped by the evolutionary selection pressure of APOBEC3 host restriction factors.
Population
Genomes of 33,400 human viruses
Comparison
Depletion of APOBEC3-favored motifs across viral genomes
Design
Genomic bioinformatic analysis
Authors
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APOBEC3 shapes viral evolution broadly; leaves open therapeutic targeting pending human validation.
APOBEC3 enzymes exert a significant evolutionary selection pressure on at least 22% of human viral species, leaving a detectable footprint of depleted target motifs.
Poulain et al. (2020) studied Viral genomes (n=33,400). APOBEC3 selection pressure vs. Expected K-mer occurrence (randomized synthetic genomes) was evaluated on Depletion of APOBEC3-favored motifs (NTC or NNGANN K-mers). APOBEC3 selection pressure impacts at least 22% of all currently annotated human viral species, leaving an evolutionary footprint characterized by the depletion of APOBEC3-favored motifs.
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