Key result
Transvenous cardioversion using a single atrial lead system was feasible, with an atrial defibrillation threshold of 2.0 J in acute AF versus 9.2 J in chronic AF (P<0.01).
Why the study?
Is a single atrial lead system feasible for low-energy transvenous cardioversion, sensing, and pacing in patients with atrial fibrillation?
Is a single atrial lead system feasible for low-energy transvenous cardioversion, sensing, and pacing in patients with atrial fibrillation?
Absolute Event Rate: 2% vs 9.2%
p-value: p=< 0.01
A single atrial lead system is feasible for atrial signal detection, pacing, and low-energy defibrillation in patients with acute or chronic atrial fibrillation.
May support simplified lead systems for AF cardioversion; leaves open validation in prospective trials.
INTRODUCTION: Clinical studies have shown that electrical conversion of atrial fibrillation (AF) is feasible with transvenous catheter electrodes at low energies. We developed a single atrial lead system that allows atrial pacing, sensing, and defibrillation to improve and facilitate this new therapeutic option. METHODS AND RESULTS: The lead consists of a tripolar sensing, pacing, and defibrillation system. Two defibrillation coil electrodes are positioned on a stylet-guided lead. A ring electrode located between the two coils serves as the cathode for atrial sensing and pacing. We used this lead to cardiovert patients with acute or chronic AF. The distal coil was positioned in the coronary sinus, and the proximal coil and the ring electrode in the right atrium. R wave synchronized biphasic shocks were delivered between the two coils. Atrial signal detection and pacing were performed using the proximal coil and the ring electrode. Eight patients with acute AF (38 +/- 9 min) and eight patients with chronic AF (6.6 +/- 5 months) were included. The fluoroscopy time for lead placement was 3.5 +/- 4.3 minutes. The atrial defibrillation threshold was 2.0 +/- 1.4 J for patients with acute AF and 9.2 +/- 5.9 J for patients with chronic AF (P < 0.01). The signal amplitude detected was 1.7 +/- 1.1 mV during AF and 4.0 +/- 2.9 mV after restoration of sinus rhythm (P < 0.001). Atrial pacing was feasible at a threshold of 4.4 +/- 3.3 V (0.5-msec pulse width). CONCLUSIONS: Atrial signal detection, atrial pacing, and low-energy atrial defibrillation using this single atrial lead system is feasible in various clinical settings. This system might lead to a simpler, less invasive approach for internal atrial cardioversion.
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Heisel et al. (1997) studied Atrial fibrillation (n=16). Single atrial lead system was evaluated on Atrial defibrillation threshold (p=< 0.01). Transvenous cardioversion using a single atrial lead system was feasible, with an atrial defibrillation threshold of 2.0 J in acute AF versus 9.2 J in chronic AF (P<0.01).
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