Further Examples of Miltenberger Cell Class V, One of them Inherited with a Depressed M Antigen

The association of a variant N with a ‘new’ antigenic type of the Miltenberger sub‐system, the first example of which was described recently, has been found in three further non‐related persons. The ‘new’ Miltenberger type, Cell Class V, is defined by the reactions Vw‐ (Mi(a‐) Mur‐ Hil+, for which the ‘shortland’ symbol Mi · V is proposed. The N variant is characterized by fair to normal reactions with rabbit and Vicia graminea, but weak or negative reactions with most human anti‐N reagents. The responsible gene complex, NsMi · V, also gives rise to a variant s antigen, which reacts exaggeratedly with most anti‐s sera by the antiglobulin method, and not at all with one anti‐s in saline. The first example of the gene complex MsMi ·xs V is described, which gives rise to variant M and s, whose reactivity is quite analogous to the variant N and s observed in the other cases. The findings are discussed, in particular with regard to their bearing on the interrelationship between so‐called satellites and the main antigens of the MNSs system.