Phase-Resolved Functional Lung MRI–derived Pulmonary Arterial Pulse Wave Velocity Correlates with 12-Month Mortality in Participants with Pulmonary Hypertension: A Post Hoc Analysis of a Multicenter Study

Marius Wernz; Andreas Voskrebenzev; Filip Klimeš; Milan Speth; Robin Müller; Karen M. Olsson; Julian Glandorf; Claus P. Heussel; Ekkehard Grünig; Henning Gall; Ardeschir Ghofrani; Fritz Roller; Sebastian Harth; Helen Marshall; Paul Hughes; Andrew J. Swift; David G. Kiely; Jürgen Behr; Julien Dinkel; Dietrich Beitzke; Iréne Lang; Kai‐Helge Schmidt; Karl-Friedrich Kreitner; Thomas Frauenfelder; Silvia Ulrich; Okka W. Hamer; Jim M. Wild; Jens Vogel‐Claussen

doi:10.1148/ryct.250508

Key Points

To assess whether pulmonary artery pulse wave velocity measured via phase-resolved functional lung MRI relates to right ventricular function and predicts 12-month mortality in pulmonary hypertension.
Performed a post hoc analysis using data from a multicenter study of participants diagnosed with pulmonary hypertension.
Quantified pulmonary arterial pulse wave velocity noninvasively using phase-resolved functional lung MRI.
Evaluated correlations between arterial pulse wave velocity, right ventricular function indices, and all-cause 12-month mortality.
Pulmonary arterial pulse wave velocity measured by functional lung MRI was significantly higher in individuals with pulmonary hypertension.
Elevated pulse wave velocity was independently associated with impaired right ventricular function and higher 12-month mortality.

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Implication

Post hoc multicenter analysis reveals elevated MRI-derived pulmonary pulse wave velocity links to 12-month mortality in pulmonary hypertension, indicating its value as a noninvasive prognostic tool.

Abstract

Pulmonary artery pulse wave velocity derived from phase-resolved functional lung MRI was higher in pulmonary hypertension and independently associated with right ventricular function and 12-month mortality.

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Wernz et al. (2026) studied this question.

synapsesocial.com/papers/6a971bca33d7b00ae7bbb5fb https://doi.org/10.1148/ryct.250508

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Phase-Resolved Functional Lung MRI–derived Pulmonary Arterial Pulse Wave Velocity Correlates with 12-Month Mortality in Participants with Pulmonary Hypertension: A Post Hoc Analysis of a Multicenter Study

Key Points

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Implication

Abstract

Discussion

Cite This Study

Phase-Resolved Functional Lung MRI–derived Pulmonary Arterial Pulse Wave Velocity Correlates with 12-Month Mortality in Participants with Pulmonary Hypertension: A Post Hoc Analysis of a Multicenter Study

Key Points

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Implication

Abstract

Discussion

Cite This Study

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