Key result
Social isolation stress induced cognitive dysfunction and increased ADAR1 expression in the hippocampus and frontal cortex of mice, which were recovered by re-socialization.
Social isolation stress induces cognitive deficits and increases ADAR1 expression in the brain, which can be reversed by re-socialization.
Caution against human extrapolation; leaves open whether ADAR1 mediates reversible cognitive effects of social isolation in patients.
Adenosine deaminase acting on RNA (ADAR) activity increases in response to inflammation. Social isolation stress is related to neuroinflammation; however, it remains unclear whether ADAR1 is altered in response to social isolation stress-induced cognitive deficits. To investigate our hypothesis that ADAR1 displayed patterns of change in response to social isolation stress, we addressed this issue systemically by isolating Kunming mice for 2, 4 and 8 weeks individually since postnatal 21 days to set up isolation mouse model. Furthermore, we arranged re-socialization group to evaluate the alterations of ADAR1 in the cognitive deficits recovery. The results of behavior tests showed that social isolation stress resulted in cognitive dysfunction, which was recovered by re-socialization in re-gregarious rearing group. Furthermore, the immunohistochemistry and western blot results displayed that both the immunoreactivity and protein expression of ADAR1 in the hippocampus and frontal cortex increased obviously as compared to the same age mice without isolation. The above abnormal alterations of ADAR1 were recovered by re-socialization in re-gregarious rearing group. Our study supports the hypothesis that ADAR1 is altered in mice affected by social isolation stress-induced cognitive deficits.
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Chen et al. (2016) studied Social isolation stress-induced cognitive deficits. Social isolation stress vs. Same age mice without isolation and re-socialization group was evaluated on Cognitive dysfunction and ADAR1 immunoreactivity and protein expression in the hippocampus and frontal cortex. Social isolation stress induced cognitive dysfunction and increased ADAR1 expression in the hippocampus and frontal cortex of mice, which were recovered by re-socialization.
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