Chemical and Pharmacological Studies on Enantiomerically Pure p‐Methoxytacripyrines, Promising Multi‐Target‐Directed Ligands for the Treatment of Alzheimer’s Disease

The S and R isomers of p-methoxytacripyrine, a recently developed multi-target-directed agent for the treatment of Alzheimer's disease, were investigated. The S enantiomer has emerged as a new promising drug candidate inhibiting cholinesterase activity, amyloid aggregation and showing significant neuroprotective properties against Aβ25–35-induced cytotoxicity.