The excretion of pseudouridine in the urine of 17 patients with psoriasis was significantly increased. The largest increase was found in patients with psoriatic arthritis. No correlation between the extent of psoriasis and pseudouridine excretion was found. The excretion of pseudouridine was followed in 10 of the 17 patients during treatment with anthralin or PUVA. Pseudouridine excretion decreased significantly during therapy. The possible application of pseudouridine excretion in monitoring the disease activity in psoriasis is discussed.
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Clemmensen et al. (1987) studied this question.