Covalent Coatings of Quartz Capillaries for the Electrophoretic Determination of Biologically Active Analytes

One of the main limitations of capillary electrophoresis (CE) is the sorption of basic compounds on the walls of a quartz capillary. To prevent this phenomenon in CE, supporting electrolytes with various additives that prevent the sorption of analytes due to the formation of dynamic coatings are commonly used. Alternatively, covalent coatings, which have a number of advantages and expand the analytical capabilities of CE, are used. The main methods of the formation of coatings covalently bound to the walls of a quartz capillary are considered.