Anticonvulsant activity of novel 1-(morpholinomethyl)-3-substituted isatin derivatives

A variety of novel isatin derivatives 5a – 5j and 6a – 6j were synthesized and characterized by spectroscopic means and elemental analysis. The title compounds were investigated for antiepileptic activity using MES and sc PTZ seizures tests. Neurotoxicity study was performed by the rotorod test. The relationship between the functional group variation and the biological activity of the evaluated compounds was discussed. Among the synthesized analogs, the most active one was 6f that revealed protection in MES at a dose of 30 mg/kg (i.p.) after 0.5 h and 4 h. This molecule also provided protection in the sc PTZ at a dose of 100 mg/kg (0.5 h) and 300 mg/kg (4 h).