What question did this study set out to answer?

Determine the molecular basis, antigen expression, prevalence, and anti-D alloimmunization potential of the partial D phenotype DNB to improve transfusion guidelines.

August 28, 2002Blood

DNB: a partial D with anti-D frequent in Central Europe

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Authors

FWFranz F. WagnerGerman Red Cross NENicole I. EicherUniversität Innsbruck JJJan JørgensenSwiss Red Cross

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Implication

Observational study reveals the high prevalence and alloimmunization risk of the partial DNB variant in Central Europeans, highlighting critical challenges for routine blood typing.

Key Points

Determine the molecular basis, antigen expression, prevalence, and anti-D alloimmunization potential of the partial D phenotype DNB to improve transfusion guidelines.
Evaluated 12 DNB carriers of Central European descent using standard serological D typing and molecular analysis.
Quantified red blood cell antigen density and the Rhesus index for the DNB phenotype.
Screened patient histories for allo-anti-D immunization events and measured antibody titers.
Identified DNB as an RHD(G355S) allele linked to a CDe haplotype, exhibiting approximately 6000 D antigens per red blood cell and a Rhesus index of 0.02 despite typing as normal D.
Documented five anti-D alloimmunization events among carriers, with antibody titers reaching up to 128.
Identified DNB as the most common partial D variant in white populations, with a frequency up to 1:292 in Switzerland.

Cite This Study

Wagner et al. (2002) studied this question.

synapsesocial.com/papers/6a97231396bab72bf50e5d95 https://doi.org/10.1182/blood-2002-03-0742

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Implication

Observational study reveals the high prevalence and alloimmunization risk of the partial DNB variant in Central Europeans, highlighting critical challenges for routine blood typing.

DNB: a partial D with anti-D frequent in Central Europe

Discussion

Member takes

Implication

Key Points

Cite This Study

DNB: a partial D with anti-D frequent in Central Europe

Discussion

Member takes

Implication

Key Points

Cite This Study

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