"Humors from Tumors": Diagnostic Potential of Peptides

Editorials1 March 1972"Humors from Tumors": Diagnostic Potential of PeptidesGILBERT S. GORDAN, M.D., PH.D., BETTY S. ROOF, M.D.GILBERT S. GORDAN, M.D., PH.D.Search for more papers by this author, BETTY S. ROOF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-3-501 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlbright's suggestion in 1941 that some cancers secrete a parathyroid hormone-like substance (1) was substantiated 25 years later by immunoassays in three laboratories (2-4). It now appears that Albright's term "parathyroid hormone-like" was prescient, for Riggs and colleagues (5) have confirmed and extended Roof and associates' observation (6) that ectopic parathyroid hormone differs immunologically from that elaborated by normal, adenomatous, or hyperplastic parathyroid glands. Practically, the difference can help to distinguish ectopic from primary hyperparathyroidism, but the implications are much wider.It is now clear that many nonendocrine tumors elaborate peptide hormones and enzymes. Clinically it is important that certain...References1. ALBRIGHT F: Case Records of the Massachusetts General Hospital #27461. N Engl J Med 225:789-791, 1941 CrossrefGoogle Scholar2. TASHJIANLEVINEMUNSON ALP: Immunochemical identification of parathyroid hormone in non-parathyroid neoplasms associated with hypercalcemia. J Exp Med 119:467-484, 1964 CrossrefMedlineGoogle Scholar3. BERSONYALOW SR: Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science 154:907-909, 1966 CrossrefMedlineGoogle Scholar4. SHERWOODO'RIORDANAURBACH LJG: Production of parathyroid hormone by non-parathyroid tumors. J Clin Endocrinol Metab 27:140-146, 1967 CrossrefMedlineGoogle Scholar5. RIGGSARNAUDREYNOLDS LCJ: Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer. J Clin Invest 50:2079-2083, 1971 CrossrefMedlineGoogle Scholar6. ROOFCARPENTERFINK BBD: Some thoughts on the nature of ectopic parathyroid hormones. Am J Med 50:686-691, 1971 CrossrefMedlineGoogle Scholar7. HAUGER-KLEVENE J: Asymptomatic production of ACTH: radioimmunoassay in squamous cell, oat cell and adenocarcinoma of the lung. Cancer 22:1262-1267, 1968 CrossrefMedlineGoogle Scholar8. OMENN G: Ectopic polypeptide hormone production by tumors (editorial). Ann Intern Med 72:136-138, 1970 LinkGoogle Scholar9. AMATRUDAUPTONGELFMAN TGN: Partial characterization of ACTH-like peptides in the "ectopic ACTH" syndrome (abstract 178). Proceedings of the Endocrine Society, 27-29 June 1969, p. 119 Google Scholar10. HERSHMANHIGGINS JH: Hydatidiform mole—a cause of clinical hyperthyroidism. N Engl J Med 284:573-577, 1971 CrossrefMedlineGoogle Scholar11. BERSONYALOW SR: Heterogeneity of peptide hormones in plasma as revealed by radioimmunoassay. Proceedings of XIe Reunion of French-Speaking Endocrinologists. Paris, Masson et Cie, 1971, pp. 105-135 Google Scholar12. ROSENBECKERSCHLAFF SCS: Ectopic gonadotropin production before clinical recognition of bronchogenic carcinoma. N Engl J Med 279:640-641, 1968 CrossrefMedlineGoogle Scholar13. MOOREZUPCHIKMARCON THN: Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders. Am J Dig Dis 16:1-7, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLeukemiasTHE PATHOLOGY OF LIVER CELL CANCERPathology of the Leukemic Cell or Reasons Why Some Leukemias are UnclassifiableAberrant hormone activity by tumors of gynecologic importanceHYPERADRENOCORTICISM AND ACTH-RELEASING FACTORPheochromocytoma Causing Excessive Parathyroid Hormone Production and HypercalcemiaSUBHASH C. KUKREJA, M.D., GARY K. HARGIS, M.S., IRA M. ROSENTHAL, M.D., GERALD A. WILLIAMS, M.D., F.A.C.P.Alpha-fetorprotein and carcinoembryonic antigen in a case of gastric carcinoma metastatic to the liverFetoprotein from Esophageal Squamous Cell CarcinomaJOEL SPRAGINS, M.D., W. H. HALL, M.D., H. J. WHITE, M.D.Pro-Parathyroid HormoneJOEL F. HABENER, M.D., BYRON KEMPER, PH.D. 1 March 1972Volume 76, Issue 3Page: 501-502KeywordsCancer immunotherapyEnzymesHyperparathyroidismImmunoassaysParathyroidParathyroid hormoneParathyroid tumorsPeptide hormones Issue Published: 1 March 1972 PDF downloadLoading ...