Ectopic Polypeptide Hormone Production by Tumors

Editorials1 January 1970Ectopic Polypeptide Hormone Production by TumorsGILBERT S. OMENN, M.D.GILBERT S. OMENN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-1-136 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe production of polypeptide hormones by neoplasms of nonendocrine tissues, resulting in "ectopic hormone syndromes" (1-4), is of considerable clinical and biochemical significance. Clinically, the production and release of excessive amounts of hormone by these tumors adds the effects of metabolic derangements to the neoplastic illness. Hormonal causes of rapid clinical deterioration in a cancer patient must be considered before concluding that symptoms are due to metastatic spread of tumor. Clinical manifestations of the ectopic hormone syndromes vary with the amount of hormone produced and with the course of the concomitant neoplastic disease. Most patients with oat-cell bronchogenic carcinoma whose...References1. KNOWLESSMITH JL: Extrapulmonary manifestations of bronchogenic carcinoma. New Eng J Med 262:505-510, 1960. CrossrefMedlineGoogle Scholar2. LIPSETTODELLROSENBERG MWL: Humoral syndromes associated with nonendocrine tumors. Ann Intern Med 61:733-756, 1964. LinkGoogle Scholar3. BOWERGORDAN BG: Hormonal effects of nonendocrine tumors. Ann Rev Med 16:83-118, 1965. CrossrefMedlineGoogle Scholar4. LIDDLEGIVENSNICHOLSON GJW: The ectopic ACTH syndrome. Cancer Res 25:1057-1061, 1965. MedlineGoogle Scholar5. LIDDLE G: Preliminary characterization of some ectopic hormones. Vitamins Hormones (NY) 26:293-311, 1968. CrossrefMedlineGoogle Scholar6. LAFFERTY F: Pseudohypoparathyroidism. Medicine (Balt) 45:247-260, 1966. CrossrefMedlineGoogle Scholar7. 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Author, Article, and Disclosure InformationAffiliations: Division of Medical Genetics Department of Medicine University of Washington Seattle, Wash. 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ROOF, M.D.Tyrosine Aminotransferase Induction Regulation Variant in Tissue CultureAlpha-fetoproteinCarcinoma of the Kidney Producing Multiple HormonesHormone syndromes associated with bronchogenic carcinoma 1 January 1970Volume 72, Issue 1Page: 136-138KeywordsHormonesPeptide hormones ePublished: 1 December 2008 Issue Published: 1 January 1970 PDF downloadLoading ...