Why the study?
Reference values for total pancreatectomy based on low-risk cohorts treated at expert centers were lacking.
What are the international reference values for surgical outcomes of total pancreatectomy in low-risk patients?
Population
994 patients undergoing primary total pancreatectomy across 25 international expert centers
Comparison
Low-risk TP vs TP with vascular resection, high-risk anastomosis TP, and low-risk pancreatoduodenectomy benchmarks
Design
Multicenter case-control study
Follow-up
3-month / 90-day
Key result
Low-risk total pancreatectomy established reference values of ≤37% for major complications and ≤6% for 90-day mortality, showing higher postoperative mortality than pancreatoduodenectomy.
Authors
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Provides benchmarks for low-risk TP outcomes at expert centers; extends quality metrics but leaves generalizability to broader practice open.
Case-Control (n=994)
Yes
What are the international reference values for surgical outcomes of total pancreatectomy in low-risk patients?
Total pancreatectomy carries significantly higher postoperative morbidity and mortality compared with pancreatoduodenectomy, and these newly defined reference values can serve for quality control in pancreatic surgery.
Müller et al. (2025) conducted a case-control in Pancreatic cancer or multifocal tumors (n=994). Total pancreatectomy vs. Pancreatoduodenectomy and high-risk total pancreatectomy was evaluated on Reference values for surgical outcomes including blood loss, major complications, 90-day mortality, and retrieved lymph nodes. Low-risk total pancreatectomy established reference values of ≤37% for major complications and ≤6% for 90-day mortality, showing higher postoperative mortality than pancreatoduodenectomy.