Key result
Preoperative hyperhomocysteinemia in postmenopausal women undergoing on-pump CABG was associated with increased specific complications like stroke and acute renal failure, but did not significantly increase overall hospital complications (35.29% vs 30.23%).
Why the study?
Studies investigating hyperhomocysteinemia and adverse postoperative outcomes in postmenopausal women undergoing on-pump primary isolated CABG are sparse, leaving the relationship with postoperative cardiovascular events inadequately covered.
Does hyperhomocysteinemia increase adverse postoperative outcomes in postmenopausal women undergoing on-pump primary isolated CABG?
Cohort (n=77)
Yes
Does hyperhomocysteinemia increase adverse postoperative outcomes in postmenopausal women undergoing on-pump primary isolated CABG?
Hyperhomocysteinemia in postmenopausal women undergoing on-pump CABG is associated with increased specific postoperative complications like CVA and acute renal failure, though overall one-year mortality is not significantly affected.
Answers are grounded in this paper and cite their sources.
Should not yet change preoperative management in postmenopausal CABG patients; leaves open whether hyperhomocysteinemia modification reduces stroke or renal failure risk.
Studies investigating the possible role of hyperhomocysteinemia (HHC) in increasing postoperative morbidity and mortality among postmenopausal women undergoing on-pump primary isolated coronary artery bypass grafting (CABG) surgery are sparse in the literature. The knowledge about the relationship of preoperative HHC and postoperative adverse cardiovascular events is not adequately covered. This study is initiated to ascertain the hypothesized higher prevalence of HHC in postmenopausal women with ischemic heart disease (IHD) scheduled for on-pump primary isolated CABG and tracing its association to the proposed adverse postoperative complications especially thromboembolic ones linked in the literature to HHC.
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Ahmed et al. (2019) conducted a cohort in Ischemic heart disease requiring on-pump primary isolated CABG (n=77). Hyperhomocysteinemia (HCY > 15 micro.mol/L) vs. Normal homocysteine levels (HCY < 15 micro.mol/L) was evaluated on Overall hospital complications (p=>0.05). Preoperative hyperhomocysteinemia in postmenopausal women undergoing on-pump CABG was associated with increased specific complications like stroke and acute renal failure, but did not significantly increase overall hospital complications (35.29% vs 30.23%).
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