On the Anti‐inflammatory Activity of Protamine Sulphate and of Hexadimethrine Bromide, Inhibitors of Plasma Kinin Formation

It has been suggested that plasma kinins may be responsible for some of the tissue responses to local injury Bradykinin, the first plasma kinin to be charac- terized and prepared synthetically, produces the four cardinal signs of inflammation: vasodilation (Holton & Holton, 1952), increased capillary permeability (Holdstock, Mathias & Schachter, 1957; Herxheimer & Schachter, 1959), accumulation of leucocytes (Lewis, communication to Joint Meeting of British and Scandinavian Pharmacological Societies, July 1960), and pain (Armstrong, Jepson, Keele & Stewart, 1957).