Key result
Testing hemostasis assays in patients on anticoagulants requires postponing laboratory investigation for at least 2 days after drug discontinuation or interpreting results with great caution.
Hemostasis assays in patients on anticoagulants should ideally be performed after drug discontinuation (≥2 days) to avoid interference, or interpreted with caution based on the specific drug's mechanism.
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Clinicians should interpret hemostasis assays with caution on anticoagulants; leaves open optimal per-drug washout validation in prospective studies.
Anticoagulant drugs affect directly or indirectly several coagulation parameters. This article is aimed at reviewing the problems encountered while testing patients on treatment and presents potential solutions. In general, it is recommended to postpone the performance of laboratory investigation upon discontinuation of the drug, preferably 2 days or more depending on the drug's half-life. If this strategy is unfeasible and patients remain on treatment, results of testing will likely be affected and result interpretation then requires great caution and knowledge of the peculiar and differential mechanism of action of the relevant anticoagulant drug being used.
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Armando Tripodi (2012) conducted a review in Patients on anticoagulant treatment requiring hemostasis assays. Anticoagulant drugs was evaluated. Testing hemostasis assays in patients on anticoagulants requires postponing laboratory investigation for at least 2 days after drug discontinuation or interpreting results with great caution.
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