The levels of three hydrolases, β‐glucuronidase, acid phosphatase, and cathepsin‐D were measured in rheumatoid and regenerated synovium. Only cathepsin‐D levels proved to be valuable as an index of inflammation. The levels found were: normal = 0.566 (μEq tyrosine/hr/mg protein); regenerated synovium = 0.667 ± 0.343; and rheumatoid synovium = 1.481 ± 0.487. The levels of cathepsin‐D increased in the regenerated synovium in relation to the time after synovectomy, reaching the levels of rheumatoid synovium after 3½ years.
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Granda et al. (1971) studied this question.
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