Water has been evaluated as a suitable solvent to replace formamide in the preparation of samples for capillary electrophoresis analysis. Critical aspects relevant to forensic analysis were studied to test the validity of the substitution. Correct assignment of allele labels was reproducibly performed on known samples, and size determination was found to be precise. Three hundred injections, regardless the method of preparation, may be run on a single capillary without loss of precision or resolution.
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Biega et al. (1999) studied this question.
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