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Immunofluorescence studies of erythrocytes from Mr. O. S. (group O blood donor) showing persistent mixed field polyagglutinability are reported. In addition to human and animal sera, various extracts from plant seeds (anti‐TAh, anti‐BHEe) and albumin glands of snails (anti‐AHP, anti‐ACN, anti‐ACH) were applied. There was normal release of cryptantigens following RDE treatment of OS cells. Rh receptor D was normal. In contrast, the strong reaction with anti‐A reagents from snails and Dolichos biflorus (anti‐ADb) was abnormal. The presence of one or several components of A receptor substance is discussed. 50.75% of 6,353 OS cells were immunofluorescent positive with application of snail anti‐A agglutinins. Transplantation chimerism appears unlikely. A mutation during early embryonal differentiation is suspected.
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Poschmann et al. (1973) studied this question.
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