Both geometrical isomers of the strigol analogue carba-GR24, ( E )-3-[2-(4-methyl-5-oxo-2,5-dihydrofuran-2-yl)ethylidene]-3,3a,4,8b-tetrahydro-2 H -indeno[1,2- b ]furan-2-one ( 1 ) and 7 ( Z isomer), were prepared separately. These analogues, in which the vinyl ether oxygen atom in GR24 has been replaced by a methylene function, are completely inactive for the stimulation of germination of seeds of the parasitic weeds Striga hermonthica and Orobanche crenata . Bioassays in which 1 was tested as an inhibitor of germination gave no indication as such.
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Thuring et al. (1997) studied this question.
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